The binding of botulinum neurotoxins to different peripheral neurons
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چکیده
منابع مشابه
A Novel Inhibitor Prevents the Peripheral Neuroparalysis of Botulinum Neurotoxins
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BoNTs (botulinum neurotoxins), considered to be the most toxic of all biological substances, inhibit neurotransmission through proteolytic cleavage of SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) proteins [VAMP (vesicle-associated membrane protein, or synaptobrevin), SNAP-25 (25 kDa synaptosome-associated protein) or syntaxin]. Expansion in the use of BoNTs as t...
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This review explores current evidence to demonstrate that botulinum neurotoxins (BoNTs) exert antipruritic effects. Both experimental and clinical conditions in which botulinum neurotoxins have been applied for pruritus relief will be presented and significant findings will be highlighted. Potential mechanisms underlying antipruritic effects will also be discussed and ongoing challenges and unm...
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ژورنال
عنوان ژورنال: Toxicon
سال: 2018
ISSN: 0041-0101
DOI: 10.1016/j.toxicon.2017.10.010